Description
MitoStack is a tri-component lyophilized research blend combining three compounds studied for their convergent effects on mitochondrial function and NAD+ metabolism: MOTS-c (a mitochondrial-derived peptide), 5-Amino-1MQ (a small-molecule NNMT inhibitor), and NAD+ (the nicotinamide adenine dinucleotide coenzyme). The blend pairs upstream signaling activation, NAD+ degradation pathway inhibition, and direct coenzyme supplementation in a single vial. Each component has been independently investigated in preclinical research for distinct but complementary roles in cellular energy metabolism, AMPK signaling, and age-related mitochondrial decline.
Benefits (Research Focus)
• Studied as a combined approach to mitochondrial biogenesis and NAD+ metabolism research
• Investigated for AMPK pathway activation via the MOTS-c component
• Explored for NNMT inhibition and NAD+ preservation via 5-Amino-1MQ
• Examined for direct intracellular NAD+ pool restoration
• Researched for convergent endpoints in cellular energy and longevity models
What Researchers Look At
• Mitochondrial membrane potential and oxidative phosphorylation efficiency
• AMPK phosphorylation and downstream metabolic gene expression
• Intracellular NAD+/NADH ratio and sirtuin activity (SIRT1/SIRT3)
• Adipose tissue NNMT levels and lipolysis markers
• Glucose homeostasis, insulin sensitivity, and exercise-mimetic endpoints
Quick Specs
• Form: Lyophilized white powder
• MOTS-c: 10 mg per vial
• 5-Amino-1MQ: 10 mg per vial
• NAD+: 100 mg per vial
• Total Content: 120 mg per vial
• Quantity: 1 vial
• Purity: ≥99% by HPLC (per component)
• Appearance: White to off-white lyophilizate
• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)
• Storage: Protect from light
Identity Basics
• Compound 1: MOTS-c
• Class: Mitochondrial-derived peptide (12S rRNA-encoded); 16 amino acids
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Chemical Formula: C₁₀₀H₁₅₈N₃₂O₂₂S₂
• Molecular Weight: 2174.62 g/mol
• CAS: 1627580-64-6
• Compound 2: 5-Amino-1MQ (5-Amino-1-methylquinolinium iodide)
• Class: Small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor
• Chemical Formula: C₁₀H₁₁IN₂ (iodide salt)
• Molecular Weight: 286.11 g/mol (salt); 159.21 g/mol (free base)
• CAS: 90692-39-0
• Compound 3: NAD+ (Nicotinamide Adenine Dinucleotide)
• Class: Pyridine nucleotide coenzyme
• Chemical Formula: C₂₁H₂₇N₇O₁₄P₂
• Molecular Weight: 663.43 g/mol
• CAS: 53-84-9
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
