MitoStack — 120mg Mitochondrial Blend (MOTS-c 10mg / 5-Amino-1MQ 10mg/ NAD+ 100mg)

MitoStack is a tri-component lyophilized research blend combining three compounds studied for their convergent effects on mitochondrial function and NAD+ metabolism: MOTS-c (a mitochondrial-derived peptide), 5-Amino-1MQ (a small-molecule NNMT inhibitor), and NAD+ (the nicotinamide adenine dinucleotide coenzyme). The blend pairs upstream signaling activation, NAD+ degradation pathway inhibition, and direct coenzyme supplementation in a single vial. Each component has been independently investigated in preclinical research for distinct but complementary roles in cellular energy metabolism, AMPK signaling, and age-related mitochondrial decline.

Benefits (Research Focus)

• Mitochondrial biogenesis & NAD+ metabolism — studied as a combined approach to multi-axis mitochondrial research

• AMPK pathway activation — investigated via the MOTS-c mitochondrial peptide component

• NNMT inhibition & NAD+ preservation — explored via the 5-Amino-1MQ small-molecule component

• Direct NAD+ supplementation — examined for intracellular NAD+ pool restoration

• Convergent multi-axis endpoints — researched for cellular energy, sirtuin signaling, and longevity model applications

What Researchers Look At

• Mitochondrial membrane potential and oxidative phosphorylation efficiency

• AMPK phosphorylation and downstream metabolic gene expression

• Intracellular NAD+/NADH ratio and sirtuin activity (SIRT1/SIRT3)

• Adipose tissue NNMT levels and lipolysis markers

• Glucose homeostasis, insulin sensitivity, and exercise-mimetic endpoints

Quick Specs

• Form: Lyophilized white powder

• MOTS-c: 10 mg per vial

• 5-Amino-1MQ: 10 mg per vial

• NAD+: 100 mg per vial

• Total Content: 120 mg per vial

• Quantity: 1 vial

• Appearance: White to off-white lyophilizate

• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)

• Purity: ≥99% by HPLC (per component)

• Identity: MS-verified (per COA)

• Storage: Protect from light

Identity Basics

• Compound 1: MOTS-c

• Class: Mitochondrial-derived peptide (12S rRNA-encoded); 16 amino acids

• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

• Formula / M.W.: C₁₀₀H₁₅₈N₃₂O₂₂S₂, ~2174.62 g/mol

• CAS: 1627580-64-6

• Compound 2: 5-Amino-1MQ (5-Amino-1-methylquinolinium iodide)

• Class: Small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor

• Formula / M.W.: C₁₀H₁₁IN₂, ~286.11 g/mol (iodide salt); 159.21 g/mol (free cation)

• CAS: 90692-39-0

• Compound 3: NAD+ (Nicotinamide Adenine Dinucleotide)

• Class: Pyridine nucleotide coenzyme

• Formula / M.W.: C₂₁H₂₇N₇O₁₄P₂, ~663.43 g/mol

• CAS: 53-84-9

⚠️ Disclaimer

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.

COA Verification Notice: Even if the vial label or product image states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified concentration and purity of each product, regardless of what the label or product image indicates.

Janoshik COA — Third-Party Testing

• MitoStack COA — May 28, 2026