Description
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide coenzyme found in every living cell, central to over 500 enzymatic reactions across cellular metabolism. NAD+ functions as a critical electron carrier in redox reactions during glycolysis, the citric acid cycle, and oxidative phosphorylation, and serves as a required substrate for sirtuin deacetylases (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and CD38-family NADases. Cellular NAD+ levels decline progressively with age across multiple tissues, making NAD+ a heavily studied compound in mitochondrial research, sirtuin pathway biology, DNA repair, and age-associated metabolic decline. NAD+ is investigated directly in research models alongside its precursor compounds (NMN, NR, NA, niacinamide) and pathway-modulating compounds (NNMT inhibitors, CD38 inhibitors).
Benefits (Research Focus)
• Mitochondrial coenzyme research — studied as the central electron carrier in cellular respiration and ATP synthesis
• Sirtuin pathway activation — investigated as the required substrate for SIRT1-7 deacetylase activity
• DNA repair signaling — explored for PARP enzyme function and genomic stability pathways
• Redox metabolism — examined for NAD+/NADH ratio dynamics in cellular energy research
• Age-associated decline — researched for tissue NAD+ depletion patterns in aged rodent and cell-culture models
What Researchers Look At
• Intracellular NAD+/NADH ratio and tissue NAD+ pool quantification
• Sirtuin (SIRT1/SIRT3/SIRT6) enzymatic activity and downstream deacetylation targets
• PARP enzyme function and DNA damage response markers
• Mitochondrial membrane potential and oxidative phosphorylation efficiency
• Comparative pharmacology with NAD+ precursors (NMN, NR) and NAD-preserving compounds (5-Amino-1MQ, FK866)
Quick Specs
• Form: Lyophilized white powder
• Net Content: 550 mg per vial
• Quantity: 1 vial
• Appearance: White to off-white lyophilizate
• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)
• Purity: ≥99% by HPLC
• Identity: MS-verified (per COA)
• Storage: Protect from light
Identity Basics
• Compound: Nicotinamide Adenine Dinucleotide (NAD+, oxidized form)
• Synonyms: NAD+; β-Nicotinamide adenine dinucleotide; Diphosphopyridine nucleotide (DPN); Coenzyme I
• Class: Pyridine nucleotide coenzyme; redox cofactor
• Formula / M.W.: C21H27N7O14P2, ~663.43 g/mol
• CAS: 53-84-9
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
COA Verification Notice: Even if the vial label or product image states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified concentration and purity of each product, regardless of what the label or product image indicates.
