5-Amino-1MQ — 50mg | NNMT Inhibitor

5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes NAD+ precursors and is reported to be elevated in aged adipose tissue, obese skeletal muscle, and certain tumor types. By selectively blocking NNMT, 5-Amino-1MQ is investigated for its ability to preserve cellular NAD+ pools, reduce methylation of nicotinamide to inactive 1-methylnicotinamide (1-MNA), and enhance sirtuin activity and energy metabolism. Originally characterized at the University of Florida by the Stephen O’Rahilly and Robert Kraft groups, the compound has been studied in preclinical research for body composition, adipose tissue lipolysis, glucose homeostasis, skeletal muscle aging, and metabolic disease endpoints. The 50 mg lyophilized vial format is intended for extended research protocols and bulk in vitro / preclinical assay use.

Benefits (Research Focus)

• NNMT inhibition — studied as a selective small-molecule inhibitor of nicotinamide N-methyltransferase

• NAD+ preservation — investigated for preservation of cellular NAD+ pools and downstream sirtuin pathway activity

• Adipose tissue research — explored for lipolysis markers and fat-mass partitioning in DIO rodent models

• Skeletal muscle metabolism — examined for endpoints related to muscle aging and sarcopenia models

• Metabolic signaling — researched for glucose homeostasis and insulin sensitivity endpoints in metabolic disease models

What Researchers Look At

• NNMT enzymatic activity and 1-methylnicotinamide (1-MNA) tissue concentrations

• Intracellular NAD+ / NADH ratio and downstream sirtuin (SIRT1/SIRT3) activation

• Body composition, fat mass, and lean mass partitioning in DIO rodent models

• Adipocyte lipolysis markers and adipose tissue inflammation profiles

• Glucose tolerance, insulin sensitivity, and hepatic steatosis endpoints

Quick Specs

• Form: Lyophilized white powder

• Net Content: 50 mg per vial (as iodide salt)

• Quantity: 1 vial

• Appearance: White to off-white lyophilizate

• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)

• Purity: ≥99% by HPLC

• Identity: MS-verified (per COA)

• Storage: Protect from light

Identity Basics

• Compound: 5-Amino-1MQ (5-Amino-1-methylquinolinium iodide)

• Synonyms: 5-Amino-1-methylquinolinium; 5-amino-1MQ iodide; NNMT inhibitor compound

• Class: Small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor

• Formula / M.W.: C₁₀H₁₁IN₂, ~286.11 g/mol (iodide salt); 159.21 g/mol (free cation portion)

• CAS: 90692-39-0

⚠️ Disclaimer

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.

COA Verification Notice: Even if the vial label or product image states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified concentration and purity of each product, regardless of what the label or product image indicates.

Janoshik COA — Third-Party Testing

• [COA links for the 5-Amino-1MQ 50mg lyo batch to be added once Janoshik testing is complete]