Description
MitoTriad is a triple-action research nasal spray combining three small-molecule and peptide compounds, each targeting a distinct axis of mitochondrial function: SS-31 (a mitochondrial-targeting tetrapeptide that stabilizes cardiolipin in the inner membrane), 5-Amino-1MQ (a small-molecule NNMT inhibitor that preserves cellular NAD+ pools), and SLU-PP-332 (a pan-ERR agonist that activates the aerobic exercise genetic program and mitochondrial biogenesis). Together, the three components address mitochondrial dysfunction from three complementary angles — protecting existing mitochondrial structure, preserving energy-currency cofactors, and driving new mitochondrial synthesis. All three actives fall within the optimal molecular weight range (159–640 Da) for efficient nasal mucosal absorption, supporting rapid systemic and central nervous system delivery.
Product Highlights
• Each vial contains 10 mL solution (~100 sprays)
• Each spray delivers 0.1 mL = 100 mcg SS-31 + 250 mcg 5-Amino-1MQ + 250 mcg SLU-PP-332
• Total SS-31 Content: 10 mg per vial
• Total 5-Amino-1MQ Content: 25 mg per vial
• Total SLU-PP-332 Content: 25 mg per vial
• Total Active Content: 60 mg per vial
• Specialized pharmaceutical-grade nasal solution — designed for comfort and ease on the nose
• Unlike many other nasal sprays, this formula avoids irritation and dryness
• Packaged in Class A, lead-free pharmaceutical glass bottles
• Tamper/Child-Proof Cap + Orifice Reducer for integrity, sterility, and ease of use
Description
MitoTriad is explored for convergent effects on mitochondrial membrane integrity (SS-31), NAD+ metabolism (5-Amino-1MQ), and mitochondrial biogenesis (SLU-PP-332), with research interest in cellular energy production, oxidative stress, mitophagy, exercise mimicry, and age-related mitochondrial decline.
Benefits
• Cardiolipin stabilization — SS-31 binds the inner mitochondrial membrane to organize electron transport chain supercomplexes
• NAD+ preservation — 5-Amino-1MQ inhibits nicotinamide N-methyltransferase to prevent NAD+ degradation
• Mitochondrial biogenesis — SLU-PP-332 activates the ERRα/PGC-1α axis driving new mitochondrial synthesis
• Exercise mimetic signaling — induces the aerobic exercise genetic response via ERR pathway activation
• Reduced oxidative stress — explored for decreased ROS leak and improved electron transport chain coupling
• Three converging axes — distinct mechanisms studied to address mitochondrial dysfunction from multiple angles simultaneously
Localized Effects with Nasal Spray
• Rapid absorption through the nasal mucosa for all three components
• Direct olfactory and trigeminal nerve pathway access to the central nervous system
• Bypasses first-pass hepatic metabolism that limits oral peptide bioavailability
• All three components (159–640 Da) fall within the optimal MW range for efficient nasal mucosal transport
• Particularly relevant for CNS mitochondrial research given direct nose-to-brain pathway
• Formulated with a specialized isotonic nasal vehicle to minimize irritation and dryness
What Researchers Use It For
• Mitochondrial membrane potential and electron transport chain supercomplex stability
• Cardiolipin oxidation and inner membrane integrity endpoints
• Intracellular NAD+/NADH ratio and sirtuin (SIRT1/SIRT3) activity
• Mitochondrial biogenesis markers (PGC-1α, NRF1, TFAM) and ERR-dependent gene programs
• Exercise capacity, endurance, and fast oxidative muscle fiber composition
• Adipose lipolysis, energy expenditure, and substrate oxidation profiles
Identity & Specs
• Compound 1: SS-31 (Elamipretide)
• Class: Mitochondrial-targeting tetrapeptide; cardiolipin-stabilizing aromatic-cationic peptide
• Sequence: D-Arg-2′,6′-dimethylTyr-Lys-Phe-NH₂
• Formula / M.W.: C₃₂H₄₉N₉O₅, ~639.79 g/mol
• CAS: 736992-21-5
• Compound 2: 5-Amino-1MQ (5-Amino-1-methylquinolinium iodide)
• Class: Small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor
• Formula / M.W.: C₁₀H₁₁IN₂, ~286.11 g/mol (iodide salt); 159.21 g/mol (free base)
• CAS: 90692-39-0
• Compound 3: SLU-PP-332
• Class: Pan-ERR (ERRα/β/γ) agonist; exercise mimetic small molecule
• Chemical Name: (E)-4-Hydroxy-N′-(naphthalen-2-ylmethylene)benzohydrazide
• Formula / M.W.: C₁₈H₁₄N₂O₂, ~290.32 g/mol
• CAS: 303760-60-3
• Form: Sterile nasal spray solution
• Net per vial: 10 mL (~100 sprays)
• Total Content: 60 mg combined active per vial
• Concentration: SS-31 1.0 mg/mL + 5-Amino-1MQ 2.5 mg/mL + SLU-PP-332 2.5 mg/mL
• Purity: ≥99% by HPLC (per component)
• Identity: MS-verified (per COA)
• Storage: Refrigerate 2–8 °C, protect from light
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
