SLU-PP-332 — 500mcg Capsules (30 Caps) | Mitochondrial

SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptor (ERR) family, developed by Thomas Burris and colleagues at Saint Louis University as a research tool compound for studying ERRα, ERRβ, and ERRγ pharmacology. The compound is studied as an “exercise mimetic” — activating the same gene expression program in skeletal muscle, adipose tissue, and brown fat that is normally induced by aerobic exercise. In published preclinical research, SLU-PP-332 administration has been associated with increased mitochondrial biogenesis, enhanced endurance capacity, fast oxidative muscle fiber shift, and significant fat-mass reduction in diet-induced obesity models without changes in food intake or activity level. Its small molecular weight (~290 Da) and oral bioavailability make it well-suited for capsule administration consistent with the published research protocols.

Benefits (Research Focus)

• Studied as a pan-ERR (ERRα / β / γ) nuclear receptor agonist

• Investigated for activation of the aerobic exercise genetic program

• Explored for mitochondrial biogenesis via PGC-1α / NRF1 / TFAM upregulation

• Examined for fat-mass reduction in diet-induced obesity models without appetite suppression

• Researched for endurance capacity and fast oxidative skeletal muscle fiber composition

What Researchers Look At

• ERRα / β / γ receptor binding affinity and transcriptional activation profiles

• Mitochondrial DNA copy number and biogenesis gene panels (PGC-1α, NRF1, TFAM)

• Body composition, fat mass, and lean mass partitioning in DIO rodent models

• Endurance capacity (treadmill exhaustion, grip strength) in trained vs sedentary animals

• Skeletal muscle fiber type composition (Type I / IIa / IIb shifts) and oxidative capacity

Quick Specs

• Form: Gelatin capsule

• Strength: 500 mcg / capsule (0.5 mg)

• Quantity: 30 capsules per bottle

• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler

• Purity: ≥99%

• Storage: Store in a cool, dry, dark place

Identity Basics

• Compound: SLU-PP-332

• Chemical Name: (E)-4-Hydroxy-N′-(naphthalen-2-ylmethylene)benzohydrazide

• Class: Pan-ERR (ERRα / β / γ) agonist; synthetic exercise mimetic small molecule

• Chemical Formula: C₁₈H₁₄N₂O₂

• Molecular Weight: 290.32 g/mol

• CAS: 303760-60-3

⚠️ Disclaimer

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.