Description
SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptor (ERR) family, developed by Thomas Burris and colleagues at Saint Louis University as a research tool compound for studying ERRα, ERRβ, and ERRγ pharmacology. The compound is studied as an “exercise mimetic” — activating the same gene expression program in skeletal muscle, adipose tissue, and brown fat that is normally induced by aerobic exercise. In published preclinical research, SLU-PP-332 administration has been associated with increased mitochondrial biogenesis, enhanced endurance capacity, fast oxidative muscle fiber shift, and significant fat-mass reduction in diet-induced obesity models without changes in food intake or activity level. Its small molecular weight (~290 Da) and oral bioavailability make it well-suited for capsule administration consistent with the published research protocols.
Benefits (Research Focus)
• Studied as a pan-ERR (ERRα / β / γ) nuclear receptor agonist
• Investigated for activation of the aerobic exercise genetic program
• Explored for mitochondrial biogenesis via PGC-1α / NRF1 / TFAM upregulation
• Examined for fat-mass reduction in diet-induced obesity models without appetite suppression
• Researched for endurance capacity and fast oxidative skeletal muscle fiber composition
What Researchers Look At
• ERRα / β / γ receptor binding affinity and transcriptional activation profiles
• Mitochondrial DNA copy number and biogenesis gene panels (PGC-1α, NRF1, TFAM)
• Body composition, fat mass, and lean mass partitioning in DIO rodent models
• Endurance capacity (treadmill exhaustion, grip strength) in trained vs sedentary animals
• Skeletal muscle fiber type composition (Type I / IIa / IIb shifts) and oxidative capacity
Quick Specs
• Form: Gelatin capsule
• Strength: 250 mcg / capsule (0.25 mg)
• Quantity: 30 capsules per bottle
• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler
• Purity: ≥99%
• Storage: Store in a cool, dry, dark place
Identity Basics
• Compound: SLU-PP-332
• Chemical Name: (E)-4-Hydroxy-N′-(naphthalen-2-ylmethylene)benzohydrazide
• Class: Pan-ERR (ERRα / β / γ) agonist; synthetic exercise mimetic small molecule
• Chemical Formula: C₁₈H₁₄N₂O₂
• Molecular Weight: 290.32 g/mol
• CAS: 303760-60-3
⚠️ Disclaimer
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This product is intended for laboratory research use only.
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Not for human or veterinary use.
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Not approved for diagnostic, therapeutic, or medical applications.
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Handle using appropriate laboratory safety procedures and personal protective equipment.
