Description
KPV is a synthetic tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH), consisting of the three C-terminal amino acids lysine-proline-valine. It is studied as one of the smallest naturally derived peptides with documented anti-inflammatory activity, retaining the immunomodulatory properties of full-length α-MSH while lacking pigmentary and central nervous system effects. KPV has been investigated in preclinical research models for its effects on inflammatory bowel disease, mast cell stabilization, atopic skin conditions, oxidative stress, and wound healing. The peptide is reported to enter cells, accumulate in the nucleus, and inhibit pro-inflammatory transcription pathways including NF-κB, with effects mediated through both melanocortin receptor binding and intracellular signaling mechanisms. Its small molecular weight (~342 Da) supports both oral and topical research applications, with capsule formulation matching the published gastrointestinal research literature.
Benefits (Research Focus)
• Studied as a synthetic α-MSH C-terminal tripeptide with anti-inflammatory properties
• Investigated for NF-κB pathway inhibition and pro-inflammatory cytokine suppression
• Explored for mast cell stabilization and histamine-related inflammation research
• Examined in colitis, IBD, and gastrointestinal inflammation preclinical models
• Researched for wound healing, atopic skin conditions, and oxidative stress endpoints
What Researchers Look At
• NF-κB nuclear translocation and inflammatory transcription factor activity
• Pro-inflammatory cytokine panels (TNF-α, IL-1β, IL-6, IL-8)
• Mast cell degranulation and histamine release in allergy / inflammation models
• Colitis severity scoring and gut mucosal integrity in DSS-colitis mouse models
• Comparative immunomodulatory pharmacology versus full-length α-MSH and other melanocortin peptides
Quick Specs
• Form: Gelatin capsule
• Strength: 500 mcg / capsule (0.5 mg)
• Quantity: 30 capsules per bottle
• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler
• Purity: ≥99%
• Storage: Store in a cool, dry, dark place
Identity Basics
• Compound: KPV
• Synonyms: Lys-Pro-Val; H-Lys-Pro-Val-OH; α-MSH (11-13)
• Class: α-MSH C-terminal tripeptide; anti-inflammatory immunomodulator
• Sequence: Lys-Pro-Val (KPV)
• Chemical Formula: C₁₆H₃₀N₄O₄
• Molecular Weight: 342.44 g/mol
• CAS: 67727-97-3
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
