Description
Cortexin® is a complex peptide preparation manufactured by Geropharm (St. Petersburg, Russia) through standardized acetic acid extraction and ultrafiltration of calf cerebral cortex tissue, yielding a defined mixture of low-molecular-weight neuropeptides, peptide fragments, and free amino acids in the approximate 1,000 – 10,000 Da molecular weight range. The preparation has been investigated in Russian academic literature (Sokolov, Skoromets, Dyakonov, and colleagues) over multiple decades for neuropeptide pharmacology, BDNF gene expression endpoints, GABAergic signaling pathway research, and cortical neuron cell research in preclinical research models. Cortexin sits alongside Cerebrolysin (Ever Pharma porcine brain preparation) as one of the two most-studied complex brain-derived polypeptide preparations in the broader academic literature. The compound is offered here as a complex polypeptide preparation for laboratory research applications, supplied as a 10 vial × 10mg presentation in the original Geropharm packaging. The compound has undergone clinical research investigation in Russia and CIS countries, though it remains an investigational research compound in US and Canadian markets without approved regulatory status.
Benefits (Research Focus)
• Complex brain peptide research — studied as a complex peptide preparation for comparative pharmacology versus other brain-derived peptide preparations (Cerebrolysin)
• BDNF pathway research — investigated for BDNF gene expression endpoints in neuronal cell research models
• Cortical neuron biology — explored for cortical neuron cell biology endpoints in cell culture research models
• GABAergic signaling research — examined for reported interactions with GABAergic signaling pathway markers in research models
• Peptide complex composition research — researched for peptide profile characterization and standardization across batches
What Researchers Look At
• BDNF gene and protein expression in neuronal cell research models
• Cortical neuron viability and morphology endpoints in cell research
• Comparative pharmacology versus Cerebrolysin (porcine brain peptide preparation)
• Peptide profile analysis and molecular weight distribution characterization
• Comparative cell research model responses across complex peptide preparations
Quick Specs
• Form: Lyophilized peptide complex (white to off-white powder)
• Net Peptide Content: 10 mg per vial
• Quantity: 10 vials per package (100 mg total)
• Manufacturing: Geropharm (St. Petersburg, Russia)
• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)
• Composition: Mixed low-molecular-weight neuropeptides and amino acids (peptide complex, not single-sequence)
• Identity: Peptide profile per manufacturer documentation
• Storage: Protect from light
Identity Basics
• Product: Cortexin (calf cerebral cortex peptide preparation)
• Synonyms: Cortexin complex; calf brain cortex peptide hydrolysate; cerebral cortex polypeptide preparation
• Class: Complex peptide preparation; not a single-sequence peptide
• Source: Acetic acid extraction and ultrafiltration of calf cerebral cortex tissue
• Composition: Mixed low-molecular-weight neuropeptides and amino acid fragments (approximately 1,000 – 10,000 Da molecular weight range)
• Manufacturer: Geropharm (St. Petersburg, Russia)
• Package format: 10 vials × 10 mg per vial (100 mg total per package)
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
- Not for pediatric research applications outside controlled laboratory settings.
Manufacturer Verification Notice: This product is supplied in its original Geropharm-manufactured packaging with manufacturer-issued batch number and expiration date. Verification of authenticity relies on Geropharm manufacturer documentation rather than third-party laboratory analysis (which is the standard for synthetic research peptides). Customers should verify package integrity, intact original packaging, and visible batch/expiration markings upon receipt.
Manufacturer Documentation
• Manufacturer: Geropharm (St. Petersburg, Russia)
• Russian Federation Registration Number: ЛП-№(000636)-(РГ-RU)
• Verification: Each package includes Geropharm-issued batch number and expiration date for manufacturer traceability
• Third-Party Testing Note: Independent third-party HPLC purity testing (such as Janoshik analysis) applies to single-sequence synthetic research peptides. Cortexin is a complex peptide preparation supplied in its original manufacturer packaging and is verified by Geropharm batch documentation rather than third-party single-peptide analysis.
