Description
IDRA-21 is a synthetic small-molecule benzothiadiazide derivative studied as an ampakine — a positive allosteric modulator of the AMPA-type ionotropic glutamate receptor. Originally developed at the University of Illinois and Cortex Pharmaceuticals as part of the broader ampakine research program, IDRA-21 is investigated for its ability to slow the desensitization rate of AMPA receptors, thereby prolonging glutamatergic excitatory postsynaptic currents and enhancing synaptic transmission in the cortex and hippocampus. The compound has been examined in preclinical research models for cognitive enhancement, learning and memory consolidation, long-term potentiation (LTP), and as a tool compound for probing AMPA receptor pharmacology. Its small molecular weight (~228 Da) and lipophilic character support oral bioavailability and efficient blood-brain barrier penetration, consistent with the oral dosing used in the published preclinical literature.
Benefits (Research Focus)
• Studied as a positive allosteric modulator of AMPA-type glutamate receptors
• Investigated for slowed AMPA receptor desensitization kinetics
• Explored for enhanced long-term potentiation (LTP) in hippocampal slice models
• Examined for cognitive performance and memory consolidation in rodent research
• Researched as a tool compound for AMPA receptor pharmacology investigations
What Researchers Look At
• AMPA receptor desensitization kinetics and excitatory postsynaptic current duration
• Long-term potentiation (LTP) magnitude and persistence in hippocampal slices
• BDNF and CREB pathway transcriptional response to ampakine signaling
• Cognitive endpoints in Morris water maze, novel object recognition, and passive avoidance tasks
• Comparative ampakine pharmacology versus CX-516, CX-717, and aniracetam
Quick Specs
• Form: Gelatin capsule
• Strength: 10 mg / capsule
• Quantity: 30 capsules per bottle
• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler
• Purity: ≥99%
• Storage: Store in a cool, dry, dark place
Identity Basics
• Compound: IDRA-21
• Synonyms: IDRA21; 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
• Class: Ampakine; AMPA receptor positive allosteric modulator; benzothiadiazide derivative
• Chemical Formula: C₈H₉ClN₂O₂S
• Molecular Weight: 232.69 g/mol
• CAS: 22503-72-6
⚠️ Disclaimer
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This product is intended for laboratory research use only.
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Not for human or veterinary use.
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Not approved for diagnostic, therapeutic, or medical applications.
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Handle using appropriate laboratory safety procedures and personal protective equipment.
