Description
PE-22-28 is a synthetic 7-amino-acid peptide derived from spadin (PE 12-28), itself a fragment of the neurotensin pro-sortilin propeptide. It is studied for its selective inhibition of the TREK-1 (KCNK2) potassium channel — a target implicated in depression, neurogenesis, and neuroprotective signaling pathways.
Product Highlights
• Each vial contains 10 mL solution (~100 sprays)
• Each spray delivers 0.1 mL = 100 mcg PE-22-28
• Total PE-22-28 Content: 10 mg per vial
• Specialized pharmaceutical-grade nasal solution — designed for comfort and ease on the nose
• Unlike many other nasal sprays, this formula avoids irritation and dryness
• Packaged in Class A, lead-free pharmaceutical glass bottles
• Tamper/Child-Proof Cap + Orifice Reducer for integrity, sterility, and ease of use
Description
PE-22-28 is explored for selective TREK-1 channel inhibition (IC₅₀ ≈ 0.12 nM), with research interest in mood regulation, hippocampal neurogenesis, neuroprotection in ischemia models, and synaptic plasticity.
Benefits
• TREK-1 channel inhibition — studied as a potent and selective KCNK2 blocker
• Antidepressant signaling — explored in forced-swim and tail-suspension behavioral models
• Hippocampal neurogenesis — investigated for increases in newborn neuron survival
• Neuroprotection — examined in cerebral ischemia and stroke models for reduced infarct volume
• Synaptogenesis — linked to synaptic protein expression and plasticity research
• Pancreatic β-cell survival — explored in islet apoptosis and diabetes models
Localized Effects with Nasal Spray
• Rapid uptake through the nasal mucosa
• Direct olfactory and trigeminal nerve pathway access to the central nervous system
• Bypasses first-pass hepatic metabolism that limits oral peptide bioavailability
• Particularly relevant for PE-22-28 given its central TREK-1 targets in brain tissue
• Formulated with a specialized isotonic nasal vehicle to minimize irritation and dryness
What Researchers Use It For
• TREK-1 / KCNK2 channel pharmacology and electrophysiology studies
• Depression and anxiety behavioral model research (FST, TST, NSF)
• Hippocampal neurogenesis and BrdU/doublecortin labeling endpoints
• Stroke and cerebral ischemia neuroprotection in rodent MCAO models
• Synaptic plasticity, LTP, and synaptogenesis pathway research
• β-cell survival and CREB signaling investigations
Identity & Specs
• Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg (7 amino acids; H-GVSWGLR-OH)
• Formula / M.W.: C₃₅H₅₅N₁₁O₉, ~773.89 g/mol
• CAS: 1801959-12-5
• Form: Sterile nasal spray solution
• Net per vial: 10 mL (~100 sprays)
• Total Content: 10 mg PE-22-28 per vial
• Concentration: 1 mg/mL (100 mcg per 0.1 mL spray)
• Purity: ≥99% (HPLC)
• Identity: MS-verified (per COA)
• Storage: Refrigerate 2–8 °C, protect from light
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
