Description
Zzz Sleep is a triple-action research nasal spray combining three small CNS-active peptides, each targeting a distinct axis of sleep, stress regulation, and circadian neurobiology: Pinealon (a Khavinson tripeptide bioregulator with pineal-derived origins and serotonin pathway research interest), DSIP (Delta Sleep-Inducing Peptide, a nonapeptide associated with slow-wave sleep architecture), and Selank (a synthetic heptapeptide anxiolytic with documented neuropsychiatric research applications in Russia). Together, the three components address sleep regulation from three complementary angles — circadian / pineal signaling (Pinealon), delta-wave sleep induction (DSIP), and stress / anxiety modulation (Selank). All three components fall within the optimal molecular weight range (418–900 Da) for efficient nasal mucosal absorption and direct nose-to-brain delivery, with each component independently studied for CNS penetration and neuroactive signaling.
Product Highlights
• Each vial contains 10 mL solution (~100 sprays)
• Each spray delivers 0.1 mL = 200 mcg Pinealon + 50 mcg DSIP + 100 mcg Selank
• Total Pinealon Content: 20 mg per vial
• Total DSIP Content: 5 mg per vial
• Total Selank Content: 10 mg per vial
• Total Active Content: 35 mg per vial
• Specialized pharmaceutical-grade nasal solution — designed for comfort and ease on the nose
• Unlike many other nasal sprays, this formula avoids irritation and dryness
• Packaged in Class A, lead-free pharmaceutical glass bottles
• Tamper/Child-Proof Cap + Orifice Reducer for integrity, sterility, and ease of use
Description
Zzz Sleep is explored for convergent effects on sleep architecture (DSIP), circadian and pineal signaling (Pinealon), and stress / anxiety regulation (Selank), with research interest in slow-wave sleep dynamics, GABAergic and serotonergic pathways, neuroprotective gene expression, and stress-resilience endpoints.
Benefits
• Sleep architecture research — DSIP studied for delta-wave / slow-wave sleep induction and EEG sleep stage modulation
• Circadian / pineal signaling — Pinealon investigated for pineal-derived bioregulator activity and serotonin pathway modulation
• Anxiolytic signaling — Selank explored for stress-reduction effects without sedation in behavioral models
• Neuroprotective gene expression — Pinealon linked to epigenetic regulation of antioxidant and anti-apoptotic genes
• BDNF and GABAergic research — Selank associated with BDNF expression and GABA receptor pathway modulation
• Three converging axes — sleep induction, circadian regulation, and stress modulation studied in a single nasal vehicle
Localized Effects with Nasal Spray
• Rapid absorption through the nasal mucosa for all three components
• Direct olfactory and trigeminal nerve pathway access to the central nervous system
• Bypasses first-pass hepatic metabolism that limits oral peptide bioavailability
• All three components (418–900 Da) fall within the optimal MW range for efficient nasal transport
• Particularly relevant for sleep / CNS research given direct nose-to-brain pathway
• Formulated with a specialized isotonic nasal vehicle to minimize irritation and dryness
What Researchers Use It For
• Slow-wave sleep (SWS) and delta EEG dynamics in rodent sleep research
• Circadian rhythm and pineal-derived bioregulator pharmacology
• Anxiolytic behavioral endpoints (elevated plus maze, open field) without sedation
• Serotonin, GABA, and BDNF pathway profiling in CNS research
• Neuroprotective and antioxidant gene expression in aged or stressed models
• Comparative neuropeptide pharmacology versus melatonin and benzodiazepine receptor agonists
Identity & Specs
• Compound 1: Pinealon
• Class: Khavinson-class tripeptide bioregulator; pineal-derived short peptide
• Sequence: Glu-Asp-Arg (EDR)
• Formula / M.W.: C₁₅H₂₆N₆O₈, ~418.40 g/mol
• CAS: 175175-23-2
• Compound 2: DSIP (Delta Sleep-Inducing Peptide)
• Class: Endogenous nonapeptide associated with delta-wave sleep induction
• Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)
• Formula / M.W.: C₃₅H₄₈N₁₀O₁₅, ~848.81 g/mol
• CAS: 62568-57-4
• Compound 3: Selank
• Class: Synthetic heptapeptide anxiolytic; tuftsin analog
• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
• Formula / M.W.: C₃₃H₅₇N₁₁O₉, ~751.86 g/mol
• CAS: 129954-34-3
• Form: Sterile nasal spray solution
• Net per vial: 10 mL (~100 sprays)
• Total Content: 35 mg combined active per vial
• Concentration: Pinealon 2.0 mg/mL + DSIP 0.5 mg/mL + Selank 1.0 mg/mL
• Purity: ≥99% by HPLC (per component)
• Identity: MS-verified (per COA)
• Storage: Refrigerate 2–8 °C, protect from light
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
