Description
SS-31 (Elamipretide) is a synthetic tetrapeptide (D-Arg-2β²6β²-dimethylTyr-Lys-Phe-NH2) designed to target mitochondria. It is studied for its ability to bind cardiolipin in the inner mitochondrial membrane, supporting energy production, reducing oxidative stress, and improving cellular resilience.
Benefits
- Mitochondrial targeting β studied for stabilizing cardiolipin and improving ATP output.
- Oxidative stress reduction β linked to decreased ROS production in preclinical studies.
- Cellular resilience β explored for protection under ischemia, injury, or age-related decline.
- Cardiovascular health β clinical trials report improved cardiac function in heart failure patients.
- Muscle performance β studied for enhanced endurance and exercise tolerance.
What researchers look at
- Mechanism: binds cardiolipin in the mitochondrial inner membrane, preserving cristae structure.
- Improved mitochondrial efficiency and reduced oxidative damage in aged and diseased models.
- Cardiac and skeletal muscle performance outcomes in preclinical and clinical research.
- Exploration in neurodegenerative and metabolic disease models.
Quick Specs
- Form: Lyophilized peptide
- Net per vial: 60 mg
- Purity: β₯99% (HPLC)
- Identity: MS-verified (per COA)
- Storage: 2β8 Β°C, protect from light
Identity Basics
- Sequence: D-Arg-2β²6β²-dimethylTyr-Lys-Phe-NH2
- Formula / M.W.: C34H49N9O5, ~623.8 g/mol
- CAS: 1270615-06-3
Selected Research
- Cardiolipin binding and mitochondrial targeting (2014):
https://pubmed.ncbi.nlm.nih.gov/25062012/
- Heart failure clinical trial (ELBAT, 2016):
https://pubmed.ncbi.nlm.nih.gov/27510986/
- Mitochondrial protection review (2020):
https://pubmed.ncbi.nlm.nih.gov/32381287/
- Exercise performance in aged models (2018):
https://pubmed.ncbi.nlm.nih.gov/29321136/
β οΈΒ Disclaimer
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This product isΒ intended for laboratory research use only.
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Not for human or veterinary use.
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Not approved forΒ diagnostic, therapeutic, or medical applications.
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Handle using appropriate laboratory safety procedures and personal protective equipment.






