Pinealon — 20mg | EDR Khavinson CNS Tripeptide

Pinealon is a synthetic tripeptide bioregulator consisting of the sequence Glu-Asp-Arg (EDR), developed by the Khavinson group at the St. Petersburg Institute of Bioregulation and Gerontology in Russia. Belonging to the same “Khavinson cytomedin” class as Epithalon, Cortagen, and Chonluten, Pinealon is one of the more extensively published short-peptide bioregulators in the Russian academic literature. The compound is investigated in preclinical research (Khavinson, Anisimov, Kolchina, and colleagues; Bulletin of Experimental Biology and Medicine; Neuroendocrinology Letters) for effects on neuronal cell biology, oxidative stress markers, gene expression in CNS tissue, and neuroplasticity pathway endpoints. Pinealon has been particularly studied in rodent models of prenatal stress exposure and age-associated cognitive research, where it is examined for effects on dendritic spine biology, apoptotic markers in neuronal cell populations, and offspring neurobehavioral endpoints. Like other Khavinson short-peptide bioregulators, Pinealon is studied primarily as a research tool for tissue-specific peptide pharmacology rather than as a defined receptor agonist.

Benefits (Research Focus)

• Neuronal cell biology research — studied for short-peptide bioregulator effects on neuronal cell populations and dendritic spine biology

• Oxidative stress pathways — investigated for ROS modulation and antioxidant gene expression in cellular research models

• Neuroplasticity pathway research — explored for gene expression endpoints in CNS tissue research

• Apoptosis markers — examined for caspase pathway and cell viability endpoints in neuronal cell research

• Khavinson SAR research — researched alongside other Khavinson short-peptide bioregulators for comparative structure-activity studies

What Researchers Look At

• Dendritic spine density and morphology in neuronal cell research

• Reactive oxygen species (ROS) markers and oxidative stress gene expression panels

• Apoptotic markers (caspase-3, Bcl-2/Bax ratios) in neuronal cell models

• Comparative pharmacology versus Epithalon (AEDG), Cortagen (AEDP), and other Khavinson tetrapeptides

• Prenatal stress rodent models and offspring neurobehavioral research endpoints

Quick Specs

• Form: Lyophilized white powder

• Net Peptide Content: 20 mg per vial

• Quantity: 1 vial

• Appearance: White to off-white lyophilizate

• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)

• Purity: ≥99% by HPLC

• Identity: MS-verified (per COA)

• Storage: Protect from light

Identity Basics

• Compound: Pinealon

• Synonyms: EDR tripeptide; Glu-Asp-Arg; Khavinson pineal/CNS peptide bioregulator

• Class: Synthetic tripeptide; Khavinson bioregulator / cytomedin class; pineal-derived peptide analog

• Sequence: Glu-Asp-Arg (EDR) — 3 amino acids

• Origin: Khavinson group, St. Petersburg Institute of Bioregulation and Gerontology (Russia)

• Formula / M.W.: C₁₅H₂₆N₆O₈, ~418.41 g/mol (free peptide; varies by counter-ion / salt form)

• CAS: 175175-23-2

⚠️ Disclaimer

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.

COA Verification Notice: Even if the vial label or product image states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified concentration and purity of each product, regardless of what the label or product image indicates.

Janoshik COA — Third-Party Testing

• Pinealon Batch COA — October 20, 2025

• Pinealon VPeptide — April 23, 2026