Description
PE-22-28 is a synthetic 9-amino-acid peptide fragment derived from the C-terminal region of the neuropeptide galanin, developed as a galanin receptor research tool. The compound is studied as a selective agonist at the GalR2 (galanin receptor type 2) subtype, with reportedly weaker activity at GalR3 and minimal activity at GalR1 — a selectivity profile that distinguishes it from full-length galanin and makes it a useful research compound for dissecting GalR2-specific pharmacology. PE-22-28 has been investigated in preclinical research (Bartfai, Crawley, Lu, and colleagues) for galanin receptor selectivity, GalR2-mediated signaling cascades, hippocampal neurogenesis pathways, BDNF expression endpoints, and HPA axis research in rodent stress models. The compound is one of the few publicly available GalR2-selective peptide research tools and is used primarily for galanin receptor pharmacology and structure-activity relationship (SAR) studies of galanin C-terminal fragments.
Benefits (Research Focus)
• GalR2 receptor agonism — studied as a selective galanin receptor type 2 agonist for receptor pharmacology research
• Receptor selectivity profile — investigated for differential activity across GalR1, GalR2, and GalR3 subtypes
• BDNF pathway research — explored for BDNF gene expression endpoints in neuronal cell research models
• Hippocampal neurogenesis — examined for cellular proliferation and neuronal differentiation markers in hippocampal research
• HPA axis pharmacology — researched for stress-axis endpoint modulation in rodent research models
What Researchers Look At
• GalR1, GalR2, and GalR3 receptor binding affinity and selectivity profiles
• cAMP and PI3K/Akt signaling cascades following GalR2 agonism
• BDNF gene and protein expression in neuronal cell research models
• Cellular proliferation markers in hippocampal neurogenesis research
• Comparative pharmacology versus full-length galanin and other GalR-targeted research compounds
Quick Specs
• Form: Lyophilized white powder
• Net Peptide Content: 10 mg per vial
• Quantity: 1 vial
• Appearance: White to off-white lyophilizate
• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)
• Purity: ≥99% by HPLC
• Identity: MS-verified (per COA)
• Storage: Protect from light
Identity Basics
• Compound: PE-22-28
• Synonyms: Galanin (2-11); galanin C-terminal fragment; PE 22-28
• Class: Synthetic 9-amino-acid galanin fragment; selective GalR2 receptor agonist
• Sequence: Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr (GWTLNSAGY) — verify exact form against batch COA
• Formula / M.W.: ~970 g/mol (verify against batch COA)
• CAS: Verify against supplier COA
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
COA Verification Notice: Even if the vial label or product image states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified concentration and purity of each product, regardless of what the label or product image indicates.
Janoshik COA — Third-Party Testing
• PE-22-28 10mg Batch COA — January 16, 2026 (Janoshik verification)
