Description
PE-22-28 is a synthetic fragment of the neuropeptide galanin (residues 22–28), studied for its potential neuroprotective and mood-modulating effects. It is explored for its interactions with galanin receptors (GalR2 and GalR3) that may influence stress response, emotional balance, and neuronal plasticity.
Benefits
- Mood balance — studied for antidepressant-like activity in preclinical research.
- Stress resilience — explored for modulation of the hypothalamic-pituitary-adrenal (HPA) axis.
- Neuroprotection — interest in protecting neurons from oxidative and excitotoxic stress.
- Cognitive function — linked to improved memory and focus in animal studies.
- Sleep quality — galanin signaling associated with improved sleep regulation.
What researchers look at
- Mechanism: binds primarily to GalR2 and GalR3 receptors in the central nervous system.
- Influence on neurogenesis and BDNF signaling in mood-regulation pathways.
- Preclinical antidepressant and anxiolytic studies in stress and depression models.
- Potential neuroprotective and anti-inflammatory effects in brain tissue research.
Quick Specs
- Form: Lyophilized peptide
- Net per vial: 10 mg
- Purity: ≥99% (HPLC)
- Identity: MS-verified (per COA)
- Storage: 2–8 °C, protect from light
Identity Basics
- Sequence: GWTLNSAGY
- Formula / M.W.: C45H67N13O12, ~970 g/mol
- CAS: 110116-80-4
Selected Research
- Galanin fragment antidepressant activity:
https://pubmed.ncbi.nlm.nih.gov/15353204/
- PE-22-28 and GalR2-mediated signaling:
https://pubmed.ncbi.nlm.nih.gov/16303331/
- Neuroprotection and galanin system overview:
https://pubmed.ncbi.nlm.nih.gov/15837571/
- BDNF and neuroplasticity modulation studies:
https://pubmed.ncbi.nlm.nih.gov/18578991/
⚠️ Disclaimer
-
This product is intended for laboratory research use only.
-
Not for human or veterinary use.
-
Not approved for diagnostic, therapeutic, or medical applications.
-
Handle using appropriate laboratory safety procedures and personal protective equipment.
