Description
Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone naturally produced by trophoblastic cells of the placenta during pregnancy, functioning through the LH/hCG receptor (LHCGR) on gonadal cells. HCG is one of the most extensively-studied glycoprotein hormones in the academic and clinical research literature spanning multiple decades. Structurally, HCG consists of two subunits: an α-subunit (shared with LH, FSH, and TSH) and a unique β-subunit that confers specific receptor binding, coupled through non-covalent interactions with characteristic glycosylation patterns. This 5000 IU lyophilized presentation is offered for laboratory research applications investigating LH/hCG receptor pharmacology, glycoprotein hormone chemistry, gonadotropin research, and comparative pharmacology across the broader glycoprotein hormone family (LH, FSH, TSH). HCG has been characterized extensively in academic research literature for LHCGR receptor binding, cAMP/PKA signaling cascade activation, and downstream steroidogenic pathway research in cell research models. The compound is supplied here strictly for laboratory research applications and remains a research-use-only compound in this presentation.
Benefits (Research Focus)
• LH/hCG receptor pharmacology — studied for LHCGR (LH/choriogonadotropin receptor) binding activity and downstream signaling cascade research
• Glycoprotein hormone chemistry research — investigated as one of the most-characterized α/β heterodimeric glycoprotein hormones in the academic research literature
• cAMP / PKA signaling research — explored for Gs-coupled cAMP signaling cascade activation and downstream PKA pathway endpoints
• Comparative gonadotropin research — examined alongside LH, FSH, and TSH for comparative glycoprotein hormone SAR research
• Glycosylation pattern research — researched for characteristic glycosylation patterns and their effect on receptor binding, plasma half-life, and biological activity
What Researchers Look At
• LH/hCG receptor (LHCGR) binding affinity and downstream cAMP signaling cascade activation in cell research models
• Glycosylation pattern characterization and comparative research versus LH and other glycoprotein hormones
• α-subunit and β-subunit interaction chemistry and heterodimer stability research
• Comparative pharmacology versus other glycoprotein hormone research compounds (LH, FSH, TSH)
• Plasma half-life characterization and glycoform-dependent pharmacokinetic research
Quick Specs
• Form: Lyophilized white powder
• Net Content: 5000 IU per vial
• Quantity: 1 vial
• Appearance: White to off-white lyophilizate
• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)
• Purity: ≥99% (per COA)
• Identity: Verified by potency assay (IU per COA)
• Storage: Protect from light
Identity Basics
• Compound: Human Chorionic Gonadotropin (HCG)
• Synonyms: hCG; human choriogonadotropin; chorionic gonadotropin; LHCGR agonist glycoprotein hormone
• Class: Glycoprotein hormone; α/β heterodimeric protein; LH/hCG receptor agonist research compound
• Structure: α-subunit (92 amino acids, shared with LH, FSH, TSH) + β-subunit (145 amino acids, HCG-specific), non-covalently associated with characteristic glycosylation
• Origin: Naturally produced by placental trophoblast cells during pregnancy; the research-grade material offered here is derived from purified natural source
• Total Amino Acids: ~237 amino acids across both subunits
• Approximate Molecular Weight: ~36,700 Da (glycosylated heterodimer)
• CAS: 9002-61-3
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications in this presentation.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
COA Verification Notice: Even if the vial label or product image states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified IU potency and purity of each batch, regardless of what the label or product image indicates. For HCG specifically, we prioritize verified IU potency testing as underdosing is a documented industry-wide concern for grey-market glycoprotein hormone material.
Third-Party Testing
