AOD-9604 Nasal Spray 5mg – 10ml

AOD-9604 is a synthetic 16-amino-acid peptide fragment derived from the C-terminal region (residues 176–191) of human growth hormone, with an added tyrosine residue at the N-terminus. It is studied as a “lipolytic fragment” of hGH that retains the fat-metabolism effects of the parent hormone while reportedly lacking the growth-promoting and insulin-resistance effects associated with full-length GH. AOD-9604 has been investigated in preclinical and clinical research for over two decades for its effects on adipose tissue lipolysis, fatty acid oxidation, and cartilage repair, without engaging the classical GH receptor signaling pathway.

Product Highlights

• Each vial contains 10 mL solution (~100 sprays)

• Each spray delivers 0.1 mL = 50 mcg AOD-9604

• Total AOD-9604 Content: 5 mg per vial

• Specialized pharmaceutical-grade nasal solution — designed for comfort and ease on the nose

• Unlike many other nasal sprays, this formula avoids irritation and dryness

• Packaged in Class A, lead-free pharmaceutical glass bottles

• Tamper/Child-Proof Cap + Orifice Reducer for integrity, sterility, and ease of use

Description

AOD-9604 is explored for selective stimulation of lipolysis and fatty acid oxidation without GH receptor activation, with research interest in adipose tissue metabolism, body composition, cartilage and joint repair, and metabolic markers in obesity models.

Benefits

• Selective lipolysis — studied for stimulating fat breakdown without classical GH receptor engagement

• Fatty acid oxidation — investigated for increased mitochondrial β-oxidation in adipocyte models

• Reduced lipogenesis — explored for inhibition of new fat synthesis pathways

• Insulin sensitivity — examined for preserved glucose homeostasis (unlike full-length GH)

• Cartilage repair — linked to chondrocyte signaling and osteoarthritis research

• Body composition research — investigated in diet-induced obesity and metabolic syndrome models

Localized Effects with Nasal Spray

• Rapid absorption through the nasal mucosa

• Bypasses first-pass hepatic metabolism that limits oral peptide bioavailability

• Convenient alternative delivery route for repeated-dose research protocols

• AOD-9604’s smaller size (1815 Da) supports efficient nasal mucosal absorption

• Formulated with a specialized isotonic nasal vehicle to minimize irritation and dryness

What Researchers Use It For

• Adipocyte lipolysis and fatty acid oxidation pathway studies

• Body composition and visceral adipose tissue endpoints in DIO rodent models

• Insulin sensitivity and glucose homeostasis profiling

• Cartilage repair and chondrocyte signaling in osteoarthritis models

• Comparative pharmacology versus full-length GH (selectivity studies)

• GH receptor–independent metabolic signaling research

Identity & Specs

• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (16 amino acids; disulfide bridge Cys⁷–Cys¹⁴)

• Class: hGH 176–191 fragment analog; lipolytic peptide

• Formula / M.W.: C₇₈H₁₂₃N₂₃O₂₃S₂, ~1815.06 g/mol

• CAS: 221231-10-3

• Form: Sterile nasal spray solution

• Net per vial: 10 mL (~100 sprays)

• Total Content: 5 mg AOD-9604 per vial

• Concentration: 0.5 mg/mL (50 mcg per 0.1 mL spray)

• Purity: ≥99% (HPLC)

• Identity: MS-verified (per COA)

• Storage: Refrigerate 2–8 °C, protect from light

⚠️ Disclaimer

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.