Description
Eloralintide (LY3841136) is a long-acting synthetic amylin analog studied as a selective amylin receptor agonist. The peptide is conjugated to a C20 fatty diacid moiety enabling reversible albumin binding and an extended plasma half-life consistent with once-weekly subcutaneous administration. In published preclinical work, eloralintide preferentially activates the human amylin 1 receptor (AMY1R), with reported selectivity of approximately 12-fold over the calcitonin receptor (CTR) and 11-fold over AMY3R — a profile differentiating it from non-selective amylin analogs such as cagrilintide. Eloralintide is investigated in research models for receptor pharmacology, food intake regulation, body composition, and gastrointestinal tolerability endpoints.
Benefits (Research Focus)
- Studied as a selective AMY1R agonist with reduced calcitonin receptor activity
- Investigated for cAMP signaling and amylin receptor pharmacology
- Explored for food intake reduction and satiety pathway research
- Examined for body composition endpoints (fat-mass vs lean-mass change)
- Researched for conditioned-taste-avoidance and GI tolerability profiles
What Researchers Look At
- Receptor binding affinity and selectivity across AMY1R / AMY3R / CTR
- cAMP activation curves in cell lines expressing amylin receptor subtypes
- Food intake, body weight, and adipose-tissue change in DIO rodent models
- Pharmacokinetics and albumin-binding driven half-life extension
- Comparative endpoints versus cagrilintide and pramlintide
Quick Specs
- Form: Lyophilized white powder
- Net Peptide Content: 10 mg per vial
- Quantity: 1 vial
- Purity: ≥99% by HPLC
- Appearance: White to off-white lyophilizate
- Reconstitution: Bacteriostatic or sterile water (added by the end researcher)
- Storage (lyophilized): Protect from light
- Storage (reconstituted): Store at 2–8 °C; for short-term laboratory use only
Identity Basics
- Compound: Eloralintide
- Synonyms: LY3841136; LY-3841136; AMY1176
- Class: Selective amylin receptor agonist (AMY1R-preferring); long-acting amylin analog
- Modification: Lipidated with C20 fatty diacid via γGlu-γGlu linker on a Lys residue; intramolecular methylene bridge between Cys2–Cys7
- Chemical Formula: C201H319N49O65S2
- Molecular Weight: 4526.10 g/mol
- CAS: 2883634-40-8
Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
