Description
J-147 is a small-molecule curcumin derivative developed at the Salk Institute as a neuroprotective and neurotrophic research compound. Originally synthesized as a hybrid between curcumin and cyclohexyl-bisphenol A and refined from the CNB-001 scaffold, J-147 has been studied in preclinical models for its effects on mitochondrial function, synaptic signaling, and neuronal survival. Reported research targets include the mitochondrial ATP synthase α-subunit, monoamine oxidase B (MAO-B), and the dopamine transporter, with documented activity against glutamate-induced excitotoxicity and amyloid-β toxicity in cortical neuron cultures.
Benefits (Research Focus)
• Studied as a curcumin-derived neuroprotective and neurotrophic compound
• Investigated for binding to mitochondrial ATP synthase α-subunit
• Explored for MAO-B inhibition and dopamine transporter activity
• Examined in transgenic Alzheimer’s models and SAMP8 accelerated-aging mice
• Researched for cognitive performance and synaptic plasticity endpoints
What Researchers Look At
• Neuronal survival under glutamate and amyloid-β toxicity (EC₅₀ ≈ 0.1–0.3 µM)
• Long-term potentiation (LTP) and synaptic gene expression panels
• Mitochondrial membrane potential and ATP production endpoints
• Egr3, NGF, and BDNF transcriptional response
• Cognitive endpoints in aged AD and accelerated-aging mouse models
Quick Specs
• Form: Gelatin capsule
• Strength: 10 mg/capsule
• Quantity: 30 capsules per bottle
• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler
• Storage: Store in a cool, dry, dark place
Identity Basics
• Compound: J-147
• Chemical Name: N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N’-[(E)-(3-methoxyphenyl)methylene]acetohydrazide
• Chemical Formula: C₁₈H₁₇F₃N₂O₂
• Molecular Weight: 350.34 g/mol
• CAS: 1146963-51-0
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
