Description
Dihexa (PNB-0408) is a synthetic oligopeptide derived from angiotensin IV, studied as a potent activator of the hepatocyte growth factor / c-Met receptor signaling system. The compound binds HGF with sub-nanomolar affinity (Kd ≈ 65 pM) and is investigated as a synaptogenic research molecule with notable properties unusual for a peptide: oral bioavailability and blood-brain barrier permeability. Dihexa has been studied in preclinical models of cognitive function, Alzheimer’s-like neurodegeneration, and dendritic spine formation, where it has been reported to promote functional synaptogenesis with high potency in neurotrophic assays. Originally engineered at Washington State University by the Harding lab and later licensed to M3 Biotechnology, Dihexa retains the angiotensin IV pharmacophore for AT4 receptor binding while incorporating N-hexanoyl and aminohexanoic acid modifications that confer metabolic stability and lipophilic BBB penetration. Its small molecular weight (~505 Da) and lipophilic character support oral capsule administration consistent with the published research literature.
Benefits (Research Focus)
• Studied as a high-affinity potentiator of hepatocyte growth factor (HGF) signaling (Kd ≈ 65 pM)
• Investigated for c-Met receptor activation and downstream signal transduction
• Explored for functional dendritic spine formation and synaptic connectivity
• Examined in rodent models of Alzheimer’s-like cognitive impairment
• Researched as a structurally optimized angiotensin IV / AT4 receptor analog
What Researchers Look At
• HGF / c-Met receptor binding affinity and phosphorylation cascades
• Dendritic spine density and synaptic protein expression in hippocampal cultures
• Long-term potentiation (LTP) and electrophysiological endpoints in brain slice models
• Cognitive performance in aged and AD-model rodents (Morris water maze, object recognition)
• Comparative neurotrophic mimetic pharmacology versus BDNF and NGF
Quick Specs
• Form: Gelatin capsule
• Strength: 5 mg / capsule
• Quantity: 30 capsules per bottle
• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler
• Purity: ≥99%
• Storage: Store in a cool, dry, dark place
Identity Basics
• Compound: Dihexa
• Synonyms: PNB-0408; N-Hexanoyl-Tyr-Ile-(6)-aminohexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH₂
• Class: Angiotensin IV analog; HGF / c-Met activator; synaptogenic oligopeptide
• Sequence: Hexanoyl-Tyr-Ile-Ahx-NH₂
• Chemical Formula: C₂₇H₄₄N₄O₅
• Molecular Weight: 504.66 g/mol
• CAS: 1401708-83-5
⚠️ Disclaimer
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This product is intended for laboratory research use only.
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Not for human or veterinary use.
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Not approved for diagnostic, therapeutic, or medical applications.
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Handle using appropriate laboratory safety procedures and personal protective equipment.
