Vitamin C Buffered — 20mL Vial | Sodium Ascorbate

Vitamin C Buffered is a sterile 20mL multi-dose vial research formulation containing 300mg/mL vitamin C activity delivered as buffered sodium ascorbate (350mg/mL) in a physiologically-compatible isotonic solution. This formulation represents the standard buffered ascorbate research format used in academic and clinical research literature — sodium ascorbate is used in preference to ascorbic acid because ascorbic acid at high concentrations is highly acidic (pH ~2.5) and unsuitable for physiologically-compatible research applications, while sodium ascorbate at physiological pH 6.8 provides the same ascorbate activity in a research-compatible form. The formulation is prepared through triple sterile filtration using sterile deionized water as the diluent, adjusted to 0.9% saline-equivalent osmolality (isotonic with physiological plasma), buffered to pH 6.8, and preserved with 0.9% benzyl alcohol as pharmaceutical-grade multi-dose vial preservative. This 20mL vial presentation is offered for laboratory research applications investigating ascorbate pharmacology, vitamin C research, redox chemistry research, and comparative research versus other ascorbate research formulations.

Benefits (Research Focus)

• Ascorbate pharmacology research — studied as a buffered sodium ascorbate research formulation for ascorbate pharmacology and redox chemistry research

• Physiologically-compatible pH format — investigated at pH 6.8 physiological range versus acidic ascorbic acid formulations (pH ~2.5) for pH-sensitivity research

• Isotonic buffered format research — explored as an isotonic (0.9% saline-equivalent) buffered ascorbate format for physiological research applications

• Triple-filtered sterile research format — examined as a sterile triple-filtered research formulation for sterile research applications

• Multi-dose vial format research — researched in multi-dose vial format with benzyl alcohol preservative for sterile multi-draw research applications

What Researchers Look At

• Ascorbate concentration verification and stability characterization in buffered isotonic formulation

• pH stability across the 6.8 physiological range and buffer capacity research

• Comparative research versus ascorbic acid (acidic form) and other ascorbate formulations

• Sterile filtration validation and multi-dose vial preservation stability

• Redox chemistry research and ascorbate oxidation kinetics in isotonic buffered format

Quick Specs

• Form: Sterile liquid multi-dose vial

• Volume: 20 mL per vial

• Container: Glass vial with yellow cap and rubber stopper

• Vitamin C Activity: 300 mg/mL (6,000 mg total per vial)

• Sodium Ascorbate Source: 350 mg/mL (7,000 mg total per vial)

• Diluent: Sterile deionized water

• Tonicity: 0.9% saline-equivalent (isotonic with physiological plasma)

• Buffer: pH 6.8 (physiologically-compatible)

• Filtration: Triple filtered (sterile filtration)

• Preservative: Benzyl alcohol 0.9% (pharmaceutical-grade, multi-dose vial preservation)

• Storage: Protect from light

Identity Basics

• Active Compound: Sodium Ascorbate (buffered form of L-Ascorbic Acid / Vitamin C)

• Synonyms: Sodium L-ascorbate; buffered vitamin C; sodium salt of L-ascorbic acid; ascorbate sodium

• Class: Water-soluble vitamin research formulation; buffered ascorbate; sodium salt of ascorbic acid

• Chemical relationship: Sodium ascorbate ≈ 86% ascorbate activity by weight (350mg/mL sodium ascorbate provides ~300mg/mL vitamin C activity)

• Vitamin C Formula: C₆H₈O₆ (ascorbic acid), MW ~176.12 g/mol

• Sodium Ascorbate Formula: C₆H₇NaO₆, MW ~198.11 g/mol

• CAS: Ascorbic Acid CAS 50-81-7; Sodium Ascorbate CAS 134-03-2

• Benzyl Alcohol Preservative: C₇H₈O, MW ~108.14 g/mol, CAS 100-51-6

⚠️ Disclaimer

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Serious documented contraindications: High-concentration ascorbate formulations are contraindicated in individuals with G6PD (glucose-6-phosphate dehydrogenase) deficiency due to documented risk of acute hemolytic anemia, which can be fatal. Additional contraindications include history of calcium oxalate kidney stones, hemochromatosis (iron overload disorders), and severe renal impairment. Individuals with these conditions should not use high-concentration ascorbate formulations without medical screening and supervision.
• Do not use in individuals with known hypersensitivity to benzyl alcohol.
• Handle using appropriate laboratory safety procedures and personal protective equipment.

COA Verification Notice: Even if the vial label states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified concentration and purity of each batch, regardless of what the label indicates.

Third-Party Testing

• [COA links for the Vitamin C Buffered 20mL vial batch to be added once analytical testing is complete]