Description
Thymalin is a complex peptide preparation originally developed by the Khavinson group at the St. Petersburg Institute of Bioregulation and Gerontology in Russia, produced through standardized aqueous-acetic acid extraction of calf/bovine thymus tissue. Thymalin is historically significant as the parent thymic preparation from which the Khavinson group later isolated and characterized active short peptide fractions — leading to the identification of Thymogen (Glu-Trp / EW dipeptide) and Vilon (Lys-Glu / KE dipeptide) as defined synthetic analogs of Thymalin’s active components. The preparation has been extensively studied in Russian academic literature (Khavinson, Morozov, Kuznik, Goldberg, and colleagues) over several decades for thymic peptide bioregulator pharmacology, T-lymphocyte differentiation marker research, dendritic cell maturation endpoints, and innate immune cell signaling pathway research. Thymalin is studied here as a reference complex thymic preparation for comparative pharmacology versus its synthetic dipeptide fractions (Vilon, Thymogen) and other thymic peptide research compounds (Thymosin Alpha-1). The compound has undergone clinical research investigation in Russia and CIS countries, though it remains an investigational research compound in US and Canadian markets without approved regulatory status.
Benefits (Research Focus)
• Khavinson thymic preparation research — studied as the parent complex preparation from which Thymogen (EW) and Vilon (KE) were derived
• T-lymphocyte differentiation research — investigated for T-cell maturation marker expression in thymocyte cell research
• Innate immune cell signaling — explored for dendritic cell maturation and innate immune signaling pathway endpoints
• Comparative SAR research — examined alongside synthetic Thymogen and Vilon fractions for comparative thymic peptide research
• Age-associated cellular research — researched for thymic cell biology endpoints in aged tissue research models
What Researchers Look At
• T-lymphocyte differentiation markers (CD3, CD4, CD8) in thymocyte cell research
• Dendritic cell maturation markers (CD80, CD86, MHC-II) in dendritic cell research
• Comparative pharmacology versus Vilon (KE), Thymogen (EW), and Thymosin Alpha-1 (TA1)
• Peptide profile analysis and standardization across batches
• Aged-tissue versus young-tissue model responses in comparative thymic cell research
Quick Specs
• Form: Lyophilized peptide complex (white to off-white powder)
• Net Peptide Content: 10 mg per vial
• Quantity: 1 vial
• Manufacturing: GMP-manufactured at supplier facility
• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)
• Composition: Mixed low-molecular-weight thymic peptides (peptide complex, not single-sequence)
• Identity: Peptide profile per supplier documentation
• Storage: Protect from light
Identity Basics
• Compound: Thymalin (bovine thymus peptide complex)
• Synonyms: Thymalin complex; calf thymus peptide hydrolysate; Khavinson thymic preparation; parent thymic complex of Thymogen/Vilon
• Class: Complex peptide preparation; not a single-sequence peptide; Khavinson-tradition thymic bioregulator
• Source: Aqueous-acetic acid extraction of calf/bovine thymus tissue under GMP conditions
• Composition: Mixed low-molecular-weight thymic peptides and amino acid fragments (~1000-5000 Da peptide range)
• Origin: Khavinson group, St. Petersburg Institute of Bioregulation and Gerontology (Russia)
• CAS: 61566-93-0 (Thymalin complex category)
⚠️ Disclaimer
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This product is intended for laboratory research use only.
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Not for human or veterinary use.
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Not approved for diagnostic, therapeutic, or medical applications.
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Handle using appropriate laboratory safety procedures and personal protective equipment.
COA Verification Notice: Even if the vial label or product image states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified concentration and purity of each product, regardless of what the label or product image indicates.
Third-Party Testing
• [COA links for the Thymalin batch to be added — note that complex peptide preparations are characterized by peptide profile analysis rather than single-sequence HPLC purity standards]
