Description
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from adrenocorticotropic hormone (ACTH 4–10).
It is studied for its effects on attention, memory, stress resilience, and post-stroke recovery, with research interest in neurotrophin pathways.
Product Highlights
- Each vial contains 10 mL solution (~100 sprays)
- Each spray delivers 0.1 mL = 100 mcg Semax
- Total Semax Content: 10 mg per vial
- Specialized pharmaceutical-grade nasal solution — designed for comfort and ease on the nose
- Unlike many other nasal sprays, this formula avoids irritation and dryness
- Packaged in Class A, lead-free pharmaceutical glass bottles
- Tamper/Child-Proof Cap + Orifice Reducer for integrity, sterility, and ease of use
Description
Semax is explored for its potential in cognitive enhancement, neuroprotection, and stroke rehabilitation.
Research suggests links to BDNF/NGF pathways, neuroplasticity, and modulation of stress and ischemic responses.
Benefits
- Attention and focus — studied for enhancing task performance and cognitive clarity
- Memory support — linked to improved recall and learning efficiency in research models
- Stress resilience — explored for modulating responses to acute and chronic stress
- Stroke recovery — clinical programs report increased BDNF and motor recovery benefits
- Neuroplasticity — associated with BDNF/TrkB and NGF signaling pathways
Localized Effects with Nasal Spray
- Rapid uptake through the nasal mucosa
- Direct access to central nervous system pathways linked to cognition and stress modulation
- Formulated with a specialized isotonic nasal vehicle to minimize irritation and dryness
What Researchers Use It For
- Mechanistic link to neurotrophins (BDNF/NGF) and plasticity pathways
- Transcriptomic responses in ischemic cortex models
- Clinical trials in Russia exploring cognition, attention, and stroke recovery
- Anti-aggregation properties studied in Aβ–metal interaction models
Identity & Specs
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
- Formula / M.W.: C37H51N9O10S, ~813.9 g/mol
- CAS: 80714-61-0
- Form: Sterile nasal spray solution
- Net per vial: 10 mL (~100 sprays)
- Total Content: 10 mg Semax per vial
- Purity: ≥99% (HPLC)
- Identity: MS-verified (per COA)
- Storage: Refrigerate 2–8 °C, protect from light
Selected Research
- PubChem entry — chemical identity:
https://pubchem.ncbi.nlm.nih.gov/compound/Semax
- Ischemic stroke rehab study (2018) — BDNF increase & motor recovery:
https://pubmed.ncbi.nlm.nih.gov/29798983/
- Genome-wide transcriptomic responses (2014):
https://pmc.ncbi.nlm.nih.gov/articles/PMC3987924/
- Neurotrophin signaling (2006):
https://pubmed.ncbi.nlm.nih.gov/16996037/
- NGF/BDNF dynamics (2009):
https://pubmed.ncbi.nlm.nih.gov/19662538/
- Aβ–metal interaction study (ACS Chem Neurosci, 2021):
https://pubs.acs.org/doi/10.1021/acschemneuro.1c00707
⚠️ Disclaimer
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This product is intended for laboratory research use only.
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Not for human or veterinary use.
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Not approved for diagnostic, therapeutic, or medical applications.
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Handle using appropriate laboratory safety procedures and personal protective equipment.
