Description
Mazdutide (IBI362 or LY3305677) is a dual GLP-1 and glucagon receptor agonist. It is studied for its effects on weight management, glucose regulation, and cardiometabolic health, representing a new class of multi-receptor incretin peptides.
Benefits
- Weight management — studied for reducing body weight in clinical trials.
- Glucose regulation — linked to improved insulin sensitivity and glycemic control.
- Cardiometabolic support — interest in cholesterol and lipid profile improvements.
- Energy balance — explored for dual GLP-1 and glucagon receptor activity.
- Next-gen incretin — represents multi-pathway metabolic research.
What researchers look at
- Dual agonism: GLP-1 receptor activation (insulin/glucose control) + glucagon receptor stimulation (energy expenditure).
- Clinical trials in obesity and type 2 diabetes populations.
- Body weight reduction and metabolic improvements compared to GLP-1 alone.
- Long-term effects on cardiovascular and hepatic endpoints under investigation.
Quick Specs
- Form: Lyophilized peptide
- Net per vial: 10 mg
- Purity: ≥99% (HPLC)
- Identity: MS-verified (per COA)
- Storage: 2–8 °C, protect from light
Identity Basics
- Type: Dual GLP-1/glucagon receptor agonist
- Formula / M.W.: Peptide analog (varies by formulation)
- CAS: 2381089-83-2
Selected Research
- PubChem entry — chemical identity:
https://pubchem.ncbi.nlm.nih.gov/compound/155999234
- Phase 2 clinical trial — weight loss and glucose regulation (2022):
https://pubmed.ncbi.nlm.nih.gov/36477276/
- Dual GLP-1/glucagon agonist mechanism review:
https://pubmed.ncbi.nlm.nih.gov/36006191/
- Cardiometabolic outcomes in obesity and diabetes:
https://pubmed.ncbi.nlm.nih.gov/37323485/
⚠️ Disclaimer
-
This product is intended for laboratory research use only.
-
Not for human or veterinary use.
-
Not approved for diagnostic, therapeutic, or medical applications.
-
Handle using appropriate laboratory safety procedures and personal protective equipment.
Even if the vial label or product image states a certain concentration, always go by the COA for the true value. We reference the COA to determine the verified concentration and purity of each product, regardless of what the label or picture indicates.
