Description
5-Deazaflavin (TND1128) is a synthetic flavin analog studied for its self-redox properties and its activity as a mitochondrial energetic modulator. In research models, this 10-ethyl-3-methyl derivative of 5-deazaflavin has been investigated as a structural alternative to NAD+ precursors such as β-NMN, with reported effects on mitochondrial membrane potential, ATP synthesis, and neuronal morphology. The compound is hydrophobic and has been examined in preclinical work for cellular uptake into brain tissue and for effects on aging-related cellular endpoints, with most published research originating from Japanese groups exploring its potential in neurodegeneration and longevity contexts.
Benefits (Research Focus)
- Studied as a mitochondrial energetic modulator with auto-redox capability
- Investigated as a structural alternative to NAD+ precursors such as β-NMN
- Explored for effects on mitochondrial membrane potential (ΔΨm) and ATP synthesis
- Examined for cytoprotection against H₂O₂-induced oxidative stress
- Researched for effects on neuronal morphology, including axon and dendrite branching
What Researchers Look At
- Mitochondrial membrane potential and on-demand ATP synthesis index
- Cellular ATP production in cultured astrocytes and hippocampal neurons
- Axon and dendrite branching and excitatory synapse formation
- Cytoprotection in oxidative stress and Ca²⁺ overload models
- Comparative endpoints versus β-NMN in brain slice and cell-culture systems
Quick Specs
- Form: Encapsulated solid
- Strength: 10 mg/capsule
- Quantity: 30 capsules per bottle
- Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler
- Storage: Store in a cool, dry, dark place; protect from light
Identity Basics
- Compound: 5-Deazaflavin (TND1128)
- Chemical Name: 10-Ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione
- Synonyms: 3-Methyl-10-ethyl-5-deazaflavin; TND-1128
- Chemical Formula: C14H13N3O2
- Molecular Weight: 255.27 g/mol
- CAS: 59997-14-7
Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
