Description
5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes NAD+ precursors and is reported to be elevated in aged adipose tissue, obese skeletal muscle, and certain tumor types. By selectively blocking NNMT, 5-Amino-1MQ is investigated for its ability to preserve cellular NAD+ pools, reduce methylation of nicotinamide to inactive 1-methylnicotinamide (1-MNA), and enhance sirtuin activity and energy metabolism. Originally characterized at the University of Florida by the Stephen O’Rahilly and Robert Kraft groups, the compound has been studied in preclinical research for body composition, adipose tissue lipolysis, glucose homeostasis, skeletal muscle aging, and metabolic disease endpoints. Its small molecular weight (~286 Da as the iodide salt) and oral bioavailability support capsule administration consistent with the published preclinical literature.
Benefits (Research Focus)
• Studied as a selective NNMT (nicotinamide N-methyltransferase) inhibitor
• Investigated for preservation of cellular NAD+ pools and sirtuin pathway activity
• Explored for adipose tissue lipolysis and fat-mass reduction in diet-induced obesity models
• Examined for skeletal muscle aging and sarcopenia endpoints
• Researched for glucose homeostasis and insulin sensitivity in metabolic disease models
What Researchers Look At
• NNMT enzymatic activity and 1-methylnicotinamide (1-MNA) tissue concentrations
• Intracellular NAD+ / NADH ratio and downstream sirtuin (SIRT1/SIRT3) activation
• Body composition, fat mass, and lean mass partitioning in DIO rodent models
• Adipocyte lipolysis markers and adipose tissue inflammation profiles
• Glucose tolerance, insulin sensitivity, and hepatic steatosis endpoints
Quick Specs
• Form: Gelatin capsule
• Strength: 50 mg / capsule (as iodide salt)
• Quantity: 30 capsules per bottle
• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler
• Purity: ≥99%
• Storage: Store in a cool, dry, dark place
Identity Basics
• Compound: 5-Amino-1MQ (5-Amino-1-methylquinolinium iodide)
• Synonyms: 5-Amino-1-methylquinolinium; 5-amino-1MQ iodide; NNMT inhibitor compound
• Class: Small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor
• Chemical Formula: C₁₀H₁₁IN₂ (iodide salt); C₁₀H₁₁N₂⁺ (free cation)
• Molecular Weight: 286.11 g/mol (iodide salt); 159.21 g/mol (free cation portion)
• CAS: 90692-39-0
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
