Description
BAM-15 is a small-molecule mitochondrial protonophore studied for its ability to uncouple oxidative phosphorylation without depolarizing the plasma membrane. In research models, it is investigated for dissipating the mitochondrial proton gradient, increasing cellular respiration, and elevating energy expenditure. Unlike older uncouplers such as DNP, BAM-15 has been characterized in the literature for its wider tolerable concentration range and selectivity for the mitochondrial inner membrane.
Benefits (Research Focus)
- Studied as a mitochondrial-targeted protonophore uncoupler
- Explored for increasing oxygen consumption and metabolic rate
- Investigated in models of diet-induced obesity and insulin resistance
- Examined for effects on hepatic lipid accumulation and fatty liver
- Researched for selectivity over plasma-membrane depolarization
What Researchers Look At
- Mitochondrial proton gradient dissipation and ATP coupling efficiency
- Whole-body energy expenditure and substrate oxidation
- Insulin sensitivity and glycemic control
- Hepatic and adipose lipid metabolism
- Comparison with classical uncouplers (DNP, FCCP) for tolerability
Quick Specs
- Form: Gelatin Capsule
- Strength: 50 mg/capsule
- Quantity: 30 capsules per bottle
- Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler
- Storage: Store in a cool, dry, dark place
Identity Basics
- Compound: BAM-15
- Chemical Name: N5,N6-Bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
- Chemical Formula: C16H10F2N8O
- Molecular Weight: 368.30 g/mol
- CAS: 451484-50-7
Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
