Description
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA. It is studied for its role in energy regulation, insulin sensitivity, metabolic balance, and exercise performance.
Benefits
- Metabolic balance — studied for improving insulin sensitivity and glucose regulation.
- Energy support — linked to enhanced mitochondrial function and cellular energy production.
- Exercise performance — explored for boosting endurance and recovery in preclinical and early human studies.
- Healthy aging — associated with resilience against metabolic decline during aging.
- Weight management — interest in fat metabolism and body composition research.
What researchers look at
- Mechanism: activates AMPK signaling to regulate glucose and fatty acid metabolism.
- Improves exercise capacity and endurance in preclinical models and early human studies.
- Supports insulin sensitivity and protects against diet-induced metabolic dysfunction.
- Links to mitochondrial resilience and systemic energy homeostasis.
Quick Specs
- Form: Lyophilized peptide
- Net per vial: 45 mg
- Purity: ≥99% (HPLC)
- Identity: MS-verified (per COA)
- Storage: 2–8 °C, protect from light
Identity Basics
- Sequence: MRWQEMGYIFYPRKLR
- Formula / M.W.: C89H144N24O14, ~2171 g/mol
- CAS: 1338745-91-7
Selected Research
- PubChem entry — chemical identity:
https://pubchem.ncbi.nlm.nih.gov/compound/137332408
- Original discovery (2015, Cell Metabolism):
https://pubmed.ncbi.nlm.nih.gov/25623291/
- AMPK activation and metabolic regulation (review):
https://pubmed.ncbi.nlm.nih.gov/29198711/
- Exercise performance improvement (Nature, 2021):
https://pubmed.ncbi.nlm.nih.gov/33692549/
- MOTS-c and aging-related decline:
https://pubmed.ncbi.nlm.nih.gov/31235742/
⚠️ Disclaimer
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This product is intended for laboratory research use only.
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Not for human or veterinary use.
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Not approved for diagnostic, therapeutic, or medical applications.
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Handle using appropriate laboratory safety procedures and personal protective equipment.
