Description
AC-SDKP (Goralatide) is a naturally-occurring N-acetylated tetrapeptide corresponding to the N-terminal residues 1-4 of thymosin β-4 (TB4) — the same 43-amino-acid parent protein from which the well-known TB-500 research peptide (TB4 residues 17-23) is derived. AC-SDKP and TB-500 are therefore “sibling” research peptides sharing a common parent protein while representing chemically and pharmacologically distinct fragments with independent research literature histories. AC-SDKP corresponds to the N-terminal region of TB4, while TB-500 corresponds to the actin-binding domain region — different regions of the same parent protein performing different research functions. AC-SDKP is produced endogenously in vivo by prolyl oligopeptidase cleavage of the TB4 N-terminus and functions as a substrate for angiotensin-converting enzyme (ACE), giving it a short native plasma half-life (~2 minutes) and creating an interesting biological relationship with the renin-angiotensin system (RAS). The peptide has been extensively investigated in academic research literature (Rasoul, Le Meur, Aumercier, and colleagues) for antifibrotic pharmacology research, hematopoietic stem cell research, ACE substrate research, and comparative pharmacology across the broader TB4-derived research peptide family alongside TB-500. This 10mg lyophilized presentation is offered for laboratory research applications investigating ACE substrate chemistry, antifibrotic pathway research, and comparative TB4/TB-500 family fragment SAR studies.
Benefits (Research Focus)
• ACE substrate research — studied as one of the most-characterized endogenous angiotensin-converting enzyme (ACE) substrate peptides in the academic research literature
• Antifibrotic pathway research — investigated for antifibrotic signaling pathway research in cardiac, renal, and pulmonary fibrosis research models
• Hematopoietic stem cell research — explored as an endogenous negative regulator of hematopoietic stem cell proliferation research
• TGF-β pathway research — examined for TGF-β signaling cascade modulation research in cell research models
• Comparative TB4/TB-500 family research — researched as the N-terminal TB4 fragment (residues 1-4) complementary to TB-500 (TB4 residues 17-23) for comparative TB4-derived peptide family SAR studies
What Researchers Look At
• ACE (angiotensin-converting enzyme) substrate cleavage kinetics and RAS system pharmacology research
• TGF-β signaling cascade modulation and downstream fibrosis pathway markers
• Comparative pharmacology versus TB-500 (TB4 residues 17-23) — investigating pharmacology of two distinct TB4 fragments from the same parent protein
• Plasma half-life characterization and ACE-mediated degradation kinetics
• Comparative research versus full-length thymosin β-4 and other endogenous antifibrotic research peptides
Quick Specs
• Form: Lyophilized white powder
• Net Peptide Content: 10 mg per vial
• Quantity: 1 vial
• Appearance: White to off-white lyophilizate
• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)
• Purity: ≥99% by HPLC
• Identity: MS-verified (per COA)
• Storage: Protect from light
Identity Basics
• Compound: AC-SDKP (Goralatide)
• Synonyms: AC-SDKP; N-Acetyl-Seryl-Aspartyl-Lysyl-Proline; Ac-Ser-Asp-Lys-Pro; Thymosin β-4 fragment 1-4; TB4(1-4); TB-500 family N-terminal fragment; N-terminal thymosin β-4 tetrapeptide
• Class: Synthetic N-acetylated tetrapeptide; TB4 N-terminal fragment; TB-500 family research peptide; endogenous ACE substrate research compound; antifibrotic research peptide
• Sequence: Ac-Ser-Asp-Lys-Pro (acetylated N-terminus, 4 amino acids)
• Parent protein family: Thymosin β-4 (TB4) — the same 43-amino-acid parent protein from which TB-500 is also derived. AC-SDKP corresponds to TB4 residues 1-4 (N-terminal region); TB-500 corresponds to TB4 residues 17-23 (actin-binding domain region). The two fragments are chemically and pharmacologically distinct research peptides sharing a common parent protein origin.
• Endogenous origin: Naturally produced in vivo by prolyl oligopeptidase cleavage of the TB4 N-terminus
• Formula: C23H38N6O9
• Molecular Weight: ~542.58 g/mol (verify exact form/salt against batch COA)
• CAS: 61512-21-8
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Important compound distinction: This product is AC-SDKP (Goralatide), the TB4 N-terminal fragment (residues 1-4). It is a different research peptide from TB-500 (TB4 residues 17-23), which is a separate SKU in our catalog. Both are derived from the same parent protein (thymosin β-4) but represent chemically and pharmacologically distinct research peptides.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
COA Verification Notice: Even if the vial label or product image states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified concentration and purity of each product, regardless of what the label or product image indicates.
Janoshik COA — Third-Party Testing
• [COA links for the AC-SDKP (Goralatide) 10mg batch to be added once Janoshik testing is complete]
