Description
Cortagen is a synthetic tetrapeptide bioregulator with the amino acid sequence Ala-Glu-Asp-Pro (AEDP), originally identified as a primary active component of Cortexin — a peptide complex derived from cerebral cortex tissue. Developed by Vladimir Khavinson and the St. Petersburg Institute of Bioregulation and Gerontology, Cortagen belongs to the Khavinson short-peptide family, a class of 2–4 amino acid sequences studied for tissue-specific epigenetic regulation rather than classical receptor agonism. The peptide is investigated for its proposed ability to penetrate cells and interact directly with DNA and chromatin structures, with research models suggesting selective binding at AACC DNA motifs and modulation of gene expression in central nervous system tissues. Its small molecular weight (~430 Da) places it within the optimal range for efficient nasal mucosal absorption and direct nose-to-brain delivery.
Product Highlights
• Each vial contains 10 mL solution (~100 sprays)
• Each spray delivers 0.1 mL = 200 mcg Cortagen
• Total Cortagen Content: 20 mg per vial
• Specialized pharmaceutical-grade nasal solution — designed for comfort and ease on the nose
• Unlike many other nasal sprays, this formula avoids irritation and dryness
• Packaged in Class A, lead-free pharmaceutical glass bottles
• Tamper/Child-Proof Cap + Orifice Reducer for integrity, sterility, and ease of use
Description
Cortagen is explored as a Khavinson-class peptide bioregulator with research interest in epigenetic gene-expression modulation, neuronal repair, neuroinflammation balance, cognitive function, and geroprotective signaling in central nervous system models.
Benefits
• Epigenetic modulation — studied for direct DNA/chromatin interaction and AACC-motif binding affinity
• Neuroprotective signaling — investigated in cerebral ischemia and nerve transection recovery models
• Neuroinflammation balance — explored for stabilizing pro- and anti-inflammatory pathway equilibrium
• Cognitive research — examined for memory, attention, and locomotor endpoints in behavioral models
• Geroprotective effects — linked to age-associated gene expression reactivation and senescence modulation
• Tissue-specific regulation — primary central nervous system targets with secondary cardiac and immune effects
Localized Effects with Nasal Spray
• Rapid absorption through the nasal mucosa
• Direct olfactory and trigeminal nerve pathway access to the central nervous system
• Bypasses first-pass hepatic metabolism that limits oral peptide bioavailability
• Cortagen’s small size (~430 Da) supports highly efficient nasal mucosal transport
• Particularly relevant for Cortagen given its primary CNS research targets
• Formulated with a specialized isotonic nasal vehicle to minimize irritation and dryness
What Researchers Use It For
• Epigenetic regulation and chromatin remodeling pathway studies
• Gene-expression profiling in age-related transcriptomic models
• Cerebral ischemia and post-injury nerve recovery research
• Cognitive performance and locomotor behavioral endpoints
• Neuroinflammation, oxidative stress, and lipid peroxidation markers
• Comparative bioregulator pharmacology versus other Khavinson peptides (Epitalon, Pinealon, Cerluten)
Identity & Specs
• Compound: Cortagen
• Synonyms: AEDP; T-34G; H-Ala-Glu-Asp-Pro-OH; H-AEDP-OH
• Class: Khavinson-class tetrapeptide bioregulator; CNS-targeted short peptide
• Sequence: Ala-Glu-Asp-Pro (AEDP)
• Formula / M.W.: C₁₇H₂₇N₅O₈, ~430.41 g/mol
• CAS: 335591-03-2
• PubChem CID: 18439621
• Form: Sterile nasal spray solution
• Net per vial: 10 mL (~100 sprays)
• Total Content: 20 mg Cortagen per vial
• Concentration: 2.0 mg/mL (200 mcg per 0.1 mL spray)
• Purity: ≥99% (HPLC)
• Identity: MS-verified (per COA)
• Storage: Refrigerate 2–8 °C, protect from light
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
