Cortagen — 20mg | AEDP Khavinson Cortex Peptide

Cortagen is a synthetic tetrapeptide bioregulator consisting of the sequence Ala-Glu-Asp-Pro (AEDP), developed by the Khavinson group at the St. Petersburg Institute of Bioregulation and Gerontology in Russia. Belonging to the same “Khavinson cytomedin” class as Epithalon (AEDG, pineal), Cartalax (AEDL, cartilage), and Pinealon (EDR, CNS), Cortagen is the tetrapeptide identified by Khavinson and colleagues as the brain cortex peptide bioregulator. The compound is proposed to function through tissue-specific gene expression modulation in neuronal and glial cell populations. Cortagen has been investigated in the Russian academic literature (Bulletin of Experimental Biology and Medicine; Khavinson, Anisimov, Chalisova, and colleagues) for neuronal cell biology, glial cell gene expression, mitochondrial function in neurons, and age-associated CNS cell biology endpoints in preclinical research models. Like other Khavinson short-peptide bioregulators, Cortagen is studied primarily as a research tool for tissue-specific peptide pharmacology rather than as a defined receptor agonist.

Benefits (Research Focus)

• Neuronal cell biology research — studied for short-peptide bioregulator effects on neuronal cell populations

• Glial cell gene expression — investigated for astrocyte and oligodendrocyte gene expression endpoints in CNS research

• Mitochondrial pathway research — explored for cellular bioenergetics endpoints in neuronal cell research models

• Khavinson SAR research — examined alongside other Khavinson short-peptide bioregulators for comparative structure-activity studies

• Age-associated cellular research — researched for CNS cell biology endpoints in aged tissue research models

What Researchers Look At

• Gene expression panels in neuronal and glial cell research models

• Cellular bioenergetics and mitochondrial markers in neuronal cell research

• Comparative pharmacology versus Epithalon (AEDG), Pinealon (EDR), and other Khavinson peptides

• Tetrapeptide structure-activity relationships in CNS cell research models

• Aged-tissue versus young-tissue model responses in comparative neuronal cell research

Quick Specs

• Form: Lyophilized white powder

• Net Peptide Content: 20 mg per vial

• Quantity: 1 vial

• Appearance: White to off-white lyophilizate

• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)

• Purity: ≥99% by HPLC

• Identity: MS-verified (per COA)

• Storage: Protect from light

Identity Basics

• Compound: Cortagen

• Synonyms: AEDP peptide; Ala-Glu-Asp-Pro tetrapeptide; Khavinson cortex peptide bioregulator

• Class: Synthetic tetrapeptide; Khavinson bioregulator / cytomedin class; brain cortex-targeted

• Sequence: Ala-Glu-Asp-Pro (AEDP) — 4 amino acids

• Origin: Khavinson group, St. Petersburg Institute of Bioregulation and Gerontology (Russia)

• Formula / M.W.: C₁₇H₂₆N₄O₉, ~414.42 g/mol (verify against batch COA)

• CAS: Verify against supplier COA (CAS assignment varies in Khavinson literature)

⚠️ Disclaimer

• This product is intended for laboratory research use only.

• Not for human or veterinary use.

• Not approved for diagnostic, therapeutic, or medical applications.

• Handle using appropriate laboratory safety procedures and personal protective equipment.

COA Verification Notice: Even if the vial label or product image states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified concentration and purity of each product, regardless of what the label or product image indicates.

Janoshik COA — Third-Party Testing

• Cortagen 20mg VPeptide Canada — November 12, 2025