Description
Cardarine (GW-501516) is a synthetic small-molecule selective agonist of the peroxisome proliferator-activated receptor delta (PPARδ), originally developed by GlaxoSmithKline and Ligand Pharmaceuticals in the 1990s as a research tool compound for studying lipid metabolism, mitochondrial biogenesis, and endurance pharmacology. The compound is investigated in preclinical research for its ability to activate PPARδ in skeletal muscle, adipose tissue, and liver, with reported effects including upregulation of fatty acid oxidation genes, mitochondrial biogenesis via PGC-1α coactivation, fast-to-slow muscle fiber type conversion, and improved running endurance in rodent models. Unlike anabolic compounds, Cardarine acts through nuclear receptor transcriptional regulation rather than androgen pathway activation. It is one of the most extensively characterized small-molecule tools for probing PPARδ pharmacology in metabolic and exercise research models.
Benefits (Research Focus)
• Studied as a selective PPARδ (peroxisome proliferator-activated receptor delta) nuclear receptor agonist
• Investigated for fatty acid oxidation gene expression and lipid metabolism endpoints
• Explored for mitochondrial biogenesis via PGC-1α coactivation pathways
• Examined for endurance capacity and skeletal muscle fiber type conversion in rodent models
• Researched for HDL elevation and triglyceride reduction in lipid metabolism studies
What Researchers Look At
• PPARδ transcriptional activation and target gene expression panels
• Fatty acid oxidation markers (CPT1, ACOX1, FABP3) in skeletal muscle and liver
• Mitochondrial DNA copy number and biogenesis genes (PGC-1α, NRF1, TFAM)
• Endurance capacity (treadmill exhaustion time) in trained and untrained animals
• Plasma lipid profiles (HDL, LDL, triglycerides) and hepatic lipid metabolism
Quick Specs
• Form: Compressed tablet
• Strength: 20 mg / tablet
• Quantity: 50 tablets per bottle
• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade binder/filler
• Purity: ≥99%
• Storage: Store in a cool, dry, dark place
Identity Basics
• Compound: Cardarine (GW-501516)
• Synonyms: GW501516; GW-1516; Endurobol; GSK-516
• Class: Selective PPARδ agonist; non-anabolic small molecule
• Chemical Formula: C₂₁H₁₈F₃NO₃S₂
• Molecular Weight: 453.50 g/mol
• CAS: 317318-70-0
⚠️ Disclaimer
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This product is intended for laboratory research use only.
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Not for human or veterinary use.
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Not approved for diagnostic, therapeutic, or medical applications.
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Handle using appropriate laboratory safety procedures and personal protective equipment.
