Description
Hexarelin is a synthetic hexapeptide growth hormone secretagogue and analog of GHRP-6, originally characterized by the Camanni and Ghigo groups at the University of Turin in the early 1990s. The peptide functions as a potent ghrelin receptor (GHS-R1a) agonist that stimulates endogenous growth hormone release from anterior pituitary somatotropes, reportedly with approximately 2- to 3-fold greater GH-releasing potency than GHRP-6. Hexarelin has also been investigated for binding interactions with cardiac CD36 scavenger receptors, distinguishing it from more selective GHS-R agonists such as ipamorelin and giving it a unique receptor profile in research models of cardiac biology. The compound is studied in preclinical research for GHS-R1a pharmacology, somatotropic axis signaling, receptor desensitization kinetics, and cardiac tissue research, and is frequently used as a reference compound in GH secretagogue structure-activity relationship (SAR) studies.
Benefits (Research Focus)
• GHS-R1a agonism — studied as a potent ghrelin receptor agonist for somatotropic axis research
• GH release pharmacology — investigated for endogenous growth hormone release from pituitary somatotropes
• Cardiac receptor binding — explored for CD36 scavenger receptor interactions in cardiac tissue research models
• SAR comparator — examined as a reference compound versus GHRP-6, ipamorelin, and other GH secretagogues
• Receptor desensitization — researched for GHS-R desensitization kinetics and feedback mechanisms
What Researchers Look At
• GHS-R1a receptor binding affinity and potency vs other GH secretagogues
• Plasma GH and IGF-1 dynamics following hexarelin administration
• Cortisol, prolactin, and ACTH response panels (Hexarelin reportedly less selective than ipamorelin)
• CD36 scavenger receptor binding and cardiac tissue endpoints in preclinical models
• Receptor desensitization curves and tachyphylaxis patterns in chronic-dosing research
Quick Specs
• Form: Lyophilized white powder
• Net Peptide Content: 5 mg per vial
• Quantity: 1 vial
• Appearance: White to off-white lyophilizate
• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)
• Purity: ≥99% by HPLC
• Identity: MS-verified (per COA)
• Storage: Protect from light
Identity Basics
• Compound: Hexarelin
• Synonyms: Hexarelin Acetate; Examorelin; EP-23905; MF-6003
• Class: Synthetic hexapeptide; ghrelin / GHS-R1a receptor agonist; GHRP-6 analog
• Sequence: His-D-2-Methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂ (6 amino acids)
• Formula / M.W.: C47H58N12O6, ~887.04 g/mol
• CAS: 140703-51-1
⚠️ Disclaimer
- This product is intended for laboratory research use only.
- Not for human or veterinary use.
- Not approved for diagnostic, therapeutic, or medical applications.
- Handle using appropriate laboratory safety procedures and personal protective equipment.
COA Verification Notice: Even if the vial label or product image states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified concentration and purity of each product, regardless of what the label or product image indicates.
Janoshik COA — Third-Party Testing
